Biosynthesis of the indole and colchicum alkaloids
نویسندگان
چکیده
منابع مشابه
Biosynthesis of the indole and Colchicum alkaloids.
There has been enormous progress over the past fifteen years or so in our understanding of the ways in which complex natural products are synthesized in living systems. In the field of alkaloids, as elsewhere, research during the initial phase1 pin-pointed those substances which are used as the common building blocks, examples being acetic acid, ornithine and lysine for the reduced systems, and...
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Reaction of tryptamine 1 with dimethyl -3-methoxyallylidenemalonate 2 afforded N?-[4,4-bis (methoxycarbonyl)-1,3-butadienyl] tryptamine 3 which in combination with acetylchloride and pyridine in dichloromethane gave N?, N?-[acetyl]-[(4,4-dinethoxycarbonyl) 1,3butadienyl] tryptamine 4. Treatment of 3 with sodium hydroxide afforded 2H[N-(3-indolyl) ethyl] 2-oxo-3-methoxycarbonyl-1-pyridine 5. Cy...
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ژورنال
عنوان ژورنال: Pure and Applied Chemistry
سال: 1967
ISSN: 1365-3075,0033-4545
DOI: 10.1351/pac196714010117